Sexual Infectious Disease
More than 1 million sexually transmitted infections (STIs) are acquired every day worldwide, the majority of which are asymptomatic. Each year there are an estimated 374 million new infections with 1 of 4 STIs: chlamydia, gonorrhoea, syphilis and trichomoniasis.
More than 30 different bacteria, viruses and parasites are known to be transmitted through sexual contact. Eight of these pathogens are linked to the greatest incidence of sexually transmitted disease. Of these, 4 are currently curable: syphilis, gonorrhoea, chlamydia and trichomoniasis. The other 4 are viral infections which are incurable: hepatitis B, herpes simplex virus (HSV or herpes), HIV and human papillomavirus (HPV). Accurate diagnostic tests for STIs are widely used in high-income countries. These are especially useful for the diagnosis of asymptomatic infections .
The iCassette innovatively integrates all the experimental reagents, procedures and laboratory environments required for nucleic acid extraction, purification and qPCR amplification into a small fully enclosed cassette, which is equivalent to a "PCR triple room". Pre-loaded reagents do not require any liquid preparation. Users only need to load samples and then initiate the processes of nucleic acid extraction, purification and qPCR amplification in the iCassette.